Both the Ram 1500 and the Sierra 1500 have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, daytime running lights, rearview cameras, available four-wheel drive, crash mitigating brakes, lane departure warning systems, blind spot warning systems, around view monitors and rear cross-path warning.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Ram 1500 Crew Cab is safer than the Sierra 1500 Crew Cab:
| 
 | 1500 | Sierra 1500 | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| Structure | GOOD | GOOD | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 27 | 49 | 
| Neck Tension | 89 lbs. | 112 lbs. | 
| Torso | GOOD | GOOD | 
| Shoulder Deflection | .47 in | .51 in | 
| Torso Max Deflection | .59 in | .71 in | 
| Pelvis | GOOD | GOOD | 
| Head Protection | GOOD | GOOD | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 58 | 158 | 
| Neck Tension | 45 lbs. | 178 lbs. | 
| Torso | GOOD | MARGINAL | 
| Shoulder Deflection | 1.57 in | 1.65 in | 
| Shoulder Force | 402 lbs. | 446 lbs. | 
| Torso Max Deflection | .83 in | 2.13 in | 
| Torso Deflection Rate | 6 MPH | 12 MPH | 
| Pelvis | GOOD | GOOD | 
| Head Protection | GOOD | GOOD | 
For its top level performance in IIHS driver and passenger-side small overlap frontal, moderate overlap frontal, side impact, roof strength and head restraint tests, with its optional vehicle-to-vehicle front crash prevention system, with its optional vehicle-to-pedestrian front crash prevention system, and its available headlight’s “Good” rating, the Insurance Institute for Highway Safety grants the Ram 1500 the rating of “Top Safety Pick” for 2022, a rating granted to only 165 vehicles tested by the IIHS. The Sierra 1500 does not qualify as a “Top Safety Pick.”

